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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VCL
All Species:
22.73
Human Site:
S721
Identified Species:
50
UniProt:
P18206
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18206
NP_003364.1
1134
123799
S721
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Chimpanzee
Pan troglodytes
XP_001147193
1046
114802
S701
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001118118
547
59720
R238
E
L
C
A
G
K
E
R
R
E
I
L
G
T
C
Dog
Lupus familis
XP_536395
799
87306
R490
D
N
P
T
V
D
D
R
G
V
G
Q
A
A
I
Cat
Felis silvestris
Mouse
Mus musculus
Q64727
1066
116699
S721
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Rat
Rattus norvegicus
P85972
1066
116597
S721
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507189
734
80358
M424
K
S
R
M
Q
E
A
M
T
Q
E
V
S
D
V
Chicken
Gallus gallus
P12003
1135
124542
S721
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001122153
1131
124026
S722
D
E
A
I
D
T
K
S
L
L
D
A
S
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O46037
961
106284
N641
K
M
V
D
N
T
S
N
I
A
R
L
I
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P19826
1010
111904
L653
N
S
S
Q
I
A
R
L
G
N
R
V
L
M
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.1
47.7
63.4
N.A.
93.3
93
N.A.
62.5
93.2
N.A.
85.5
N.A.
42.1
N.A.
39.6
N.A.
Protein Similarity:
100
90.9
47.8
66.5
N.A.
93.9
93.5
N.A.
63.8
96.6
N.A.
93
N.A.
57.7
N.A.
56.7
N.A.
P-Site Identity:
100
100
0
6.6
N.A.
100
100
N.A.
6.6
100
N.A.
100
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
13.3
20
N.A.
100
100
N.A.
26.6
100
N.A.
100
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
55
10
0
10
10
0
0
10
0
55
10
10
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
64
0
0
10
55
10
10
0
0
0
55
0
0
10
0
% D
% Glu:
10
55
0
0
0
10
10
0
0
10
10
0
0
55
55
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
0
19
0
10
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
55
10
0
0
0
10
0
10
0
10
0
10
% I
% Lys:
19
0
0
0
0
10
55
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
0
0
0
10
55
55
0
19
10
0
0
% L
% Met:
0
10
0
10
0
0
0
10
0
0
0
0
0
10
0
% M
% Asn:
10
10
0
0
10
0
0
10
0
10
0
0
0
10
0
% N
% Pro:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
10
0
0
0
0
10
0
10
0
0
0
% Q
% Arg:
0
0
10
0
0
0
10
19
10
0
19
0
0
0
10
% R
% Ser:
0
19
10
0
0
0
10
55
0
0
0
0
64
0
0
% S
% Thr:
0
0
0
10
0
64
0
0
10
0
0
0
0
10
10
% T
% Val:
0
0
10
0
10
0
0
0
0
10
0
19
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _